A patient who is being treated for HIV infection has a 5-mm area of induration after a routine TST. The patient's chest radiograph is normal, and there are no other physical findings. The nurse will expect this patient to begin treatment with which drugs?
a. Isoniazid and rifabutin
b. Isoniazid and rifampin
c. Isoniazid and rifapentine
d. Isoniazid and pyrazinamide
ANS: A
Rifabutin is used off-label as an alternative to rifampin to treat TB in patients with HIV, because it has less impact on the metabolism of protease inhibitors. The effects of rifapentine on protease inhibitors is similar to those of rifampin. Pyrazinamide is not indicated.
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