A patient is taking oral ketoconazole [Nizoral] for a systemic fungal infection. The nurse reviews the medication administration record and notes that the patient is also taking omeprazole [Prilo-sec] for reflux disease
What action should the nurse take? a. Administer the omeprazole 1 hour before the ketoconazole.
b. Administer the omeprazole at least 2 hours after the ketoconazole.
c. Confer with the prescriber about a poten-tial hazardous interaction.
d. The nurse should not administer omepra-zole to a patient receiving ketoconazole.
B
The nurse should administer the omeprazole at least 2 hours after the ketoconazole to prevent a drug-to-drug interaction. Drugs that reduce gastric acidity should be administered no sooner than 2 hours after ingestion of ketoconazole, because they reduce absorption of the drug. There is no need to confer with the prescriber or to refuse to administer the drugs, because ketoconazole and omeprazole do not have a potentially hazardous interaction.
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