The severity of diseases inherited through mitochondrial inheritance varies and depends on the ratio of normal and abnormal mitochondria, a mixture that is called
A. heterochromatin
B. heteroplasm
C. heterotaxia
D. genetic mosaicism
E. dysgenesis
B
Heteroplasm, a mixture of normal and abnormal mitochondria in various tissues, accounts for the variable severity of mitochondrial diseases. Heterochromatin is clumped chromatin in the nucleus that remains clumped during mitosis. Heterotaxia is the technical term for abnormally located organs. Mosaicism is a juxtaposition of genetically distinct cells in the same tissues, as is sometimes seen in Turner's syndrome. Dysgenesis is abnormal development of organs or tissues.
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