A child with cystic fibrosis (CF) is receiving recombinant human deoxyribonuclease (DNase). Which is an adverse effect of this medication?
a. Mucus thickens
b. Voice alters
c. Tachycardia
d. Jitteriness
ANS: B
One of the only adverse effects of DNase is voice alterations and laryngitis. DNase decreases viscosity of mucus, is given in an aerosolized form, and is safe for children younger than 12 years. ?2 agonists can cause tachycardia and jitteriness.
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