What instructions would be important to give to a 50-year-old patient with type 2 diabetes who has been switched from glyburide (DiaBeta) to repaglinide?
A) "It is less potent, so you will need to take a larger dose."
B) "It stimulates insulin production, so you need to eat soon after taking the medication."
C) "It is more potent and longer lasting, so you should take it every other day."
D) "The two medications are virtually the same."
B
Feedback:
Glyburide is a second-generation sulfonylurea that stimulates insulin release from the beta cells in the pancreas with a 2- to 4-hour onset of action. Repaglinide has an onset of action within 30 minutes with peak effect in 1 hour, and duration of action is approximately 3 to 4 hours. Because repaglinide has a much faster onset of action, it is important the patient eats within15 to 30 minutes after taking the drug to avoid hypoglycemia. Repaglinide is not less potent, it is not more potent, and the two medications are not virtually the same.
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