Biotransformation is affected by many factors. What happens to the client's drug metabolism when liver function is decreased?
a. The client can develop toxicity.
b. The client will have an enhanced therapeutic response.
c. The client may require a larger than normal dose of the medication.
d. The client will experience a decreased therapeutic response.
ANS: A
When the drug metabolism rate is decreased, excess drug accumulation can occur and lead to the client's developing toxicity. The GI membrane is made up of lipids; therefore, lipid medications are most easily absorbed across the digestive membrane of the stomach. Medications that are nonionized (neither positive nor negative) also pass through the GI membrane faster than those with a charge.
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