A nurse is administering a diuretic that inhibits reabsorption of sodium and chloride ions in the distal and proximal tubules and in the loop of Henle. Which of the following might the nurse be administering? Select all that apply
A) Chlorothiazide
B) Furosemide
C) Bumetanide
D) Mannitol
E) Spironolactone
Ans: B, C
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Loop diuretics, like furosemide (Lasix) and bumetanide (Bumex), cause dieresis by inhibiting reabsorption of sodium and chloride ions in the distal and proximal tubules and in the loop of Henle. Thiazide and related diuretics such as chlorothiazide inhibit the reabsorption of sodium and chloride ions in the ascending portion of the loop of Henle and the early distal tubule of the nephron. Osmotic diuretics such as mannitol increase the density of the filtrate in the glomerulus. Potassium-sparing diuretics such as spironolactone work by blocking the reabsorption of sodium in the kidney tubules, thereby increasing sodium and water in the urine.
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