Which of the following statements regarding plasma-protein binding is correct?
A) Plasma-protein binding is an irreversible process that decreases the amount of medication necessary for a desired clinical effect.
B) Plasma-protein binding releases medication as circulating levels of a particular medication begin to fall, leading to a longer duration of action.
C) If a patient has a safe level of a protein-bound medication, a second medication with a greater affinity greatly decreases the amount of the original medication.
D) As plasma protein levels decrease, the introduction of another protein-bound medication causes the concentration of the original medication to remain unchanged.
Ans: B) Plasma-protein binding releases medication as circulating levels of a particular medication begin to fall, leading to a longer duration of action.
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