Differentiate between endocrine, paracrine, and autocrine. Provide an example of a cytokine that demonstrates such activity. (Different cytokines may be listed for each term.)
What will be an ideal response
See below table.
Autocrine Paracrine Endocrine
Definition Signal stimulates cell that released the signal (self-stimulation) Signal stimulates neighboring cell Signal stimulates cell in another organ; pass through bloodstream before binding receptor
Example IL-2 (T-cell differentiation to memory Ts and cytotoxic Ts [CTL])
IL-2 (stimulates B-cell proliferation, e.g., secondary immune organs—lymph node, spleen) IL-2 (causes activation of NK cells that may be present in close proximity or far away)
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a. true b. false
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