A generalized deficiency in the ability to mount delayed-type hypersensitivity (DTH) responses, as described in question 3, is called:
A. Clinical atopy
B. Clonal ignorance
C. Clinical anergy
D. Clonal deletion
E. Seroconversion
ANS: C. A generalized deficiency in delayed-type hypersensitivity (DTH) responses is called clinical anergy. Note that clonal (or lymphocyte) anergy refers to the failure of clones of T or B cells to react to antigen. Anergy may be a mechanism of maintaining immunologic tolerance to self. Atopy refers to allergic disease. Clonal ignorance and clonal deletion are mechanisms of tolerance to antigens. Seroconversion refers to the appearance in the serum of antibodies specific for a particular antigen after infection or immunization.
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