A 20-kg pediatric patient is being treated for toxoplasmosis, and the provider orders pyrimetha-mine [Daraprim] 10 mg twice daily. The nurse caring for this patient will anticipate which addi-tional order from the provider?
a. Administer 10 to 15 mg of folinic acid with each dose of pyrimethamine.
b. Give the medication intravenously over 30 to 45 minutes.
c. Increase the dose to 20 mg twice daily after 2 to 4 days.
d. Teach the family to monitor for muscle pain and joint stiffness.
A
Folinic acid is given with pyrimethamine to minimize adverse effects, and the dose is 10 to 15 mg twice daily, given with the pyrimethamine dose. The medication is given orally. The dose should be cut in half, not increased, after 2 to 4 days. Muscle pain and joint stiffness are adverse effects of sodium stibogluconate.
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