Explain the path taken by CD1 molecules that eventually bind to pathogen-derived lipids inside endosomes of the MHC class II compartment
What will be an ideal response?
CD1 begins assembly with β2-microglobulin and self lipid in the endoplasmic reticulum of restricted cell types. It progresses through the Golgi, then to Golgi-derived vesicles, and is eventually presented on the cell surface. The complex is subsequently endocytosed via clathrin-coated pits and intersects the endosomal pathway and the MHC class II compartment. Then self lipids are exchanged for pathogen-derived lipids before the complex is transported back to the cell surface for presentation to α:β T cells.
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