Which of the following molecules of RNA would you predict to be the most likely to fold into a specific structure as a result of intramolecular base-pairing?

(a) 5?-CCCUAAAAAAAAAAAAAAAAUUUUUUUUUUUUUUUUAGGG-3?
(b) 5?-UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUG-3?
(c) 5?-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-3?
(d) 5?-GGAAAAGGAGAUGGGCAAGGGGAAAAGGAGAUGGGCAAGG-3?


Choice (a) is correct. Choices (b) and (c) do not have any opportunity for intramolecular base-pairing and thus a specific structure is unlikely. Although there is some opportunity for intramolecular base-pairing in choice (d), choice (a) has much more intrastrand complementarity and is a better choice.

Biology & Microbiology

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