A 12-year-old boy has contracted a bacterial infection at school, and his body has responded by increasing leukocyte production. Place the following components of white blood cell production in the correct chronological order. Use all the options
A) Myeloblast
B) Promyelocyte
C) Myeloid stem cell
D) Metamyelocyte
E) Neutrophil
Ans:
C, A, B, D, E
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Granulocytes like neutrophils derive from the myeloid stem cells. The immature precursor cells for each of the cell lines are called blast cells. Myeloblasts, which are the granulocytic precursor cells, have round to oval nuclei, with delicate chromatin and a blue to gray cytoplasm. During the next stage of development, the myeloblasts are transformed into promyelocytes with similar nuclei, but with a cytoplasm containing many primary granules. In the subsequent metamyelocyte stage, the nuclei distort and become arclike, producing the band developmental stage. Metamyelocytes mature into neutrophils.
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