What common action do both cardiac glycosides and phosphodiesterase inhibitors have in common related to therapeutic action?
A) Blocking the enzyme phosphodiesterase
B) Increasing cellular calcium
C) Developing ventricular arrhythmias
D) Metabolizing in the liver and excreted in the urine
B
Feedback:
The phosphodiesterase inhibitors block the enzyme phosphodiesterase. This blocking effect leads to an increase in myocardial cell cyclic adenosine monophosphate (cAMP), which increases calcium levels in the cell (Figure 44.4). Increased cellular calcium causes a stronger contraction and prolongs the effects of sympathetic stimulation, which can lead to vasodilation, increased oxygen consumption, and arrhythmias. Digoxin also increases intracellular calcium and allows more calcium to enter myocardial cells during depolarization.
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Indicate whether the statement is true or false