Which of the following numbers could be the therapeutic index (TI) of a drug for which there is the greatest possibility of toxicity?
a. 2
b. 1
c. 5
d. 10
ANS: B
A drug's TI expresses the relative safety of a drug. TI relates the dose of a drug required to pro-duce a desired effect to that producing an adverse or toxic response. Drugs with a high TI are said to be safe (i.e., to have a wide margin of safety). Those with a low TI are relatively unsafe and have the narrowest margin of safety, therefore the greatest possibility of toxicity.
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