How can metabolism be affected in relation to diet-drug interactions?


?Some food components alter the activities of enzymes that metabolize drugs or may counteract drug effects in other ways. Compounds in grapefruit juice (or whole grapefruit) have been found to inhibit or inactivate enzymes that metabolize a number of different drugs. As a result of the reduced enzyme action, blood concentrations of the drugs increase, leading to stronger physiological effects. The effect of grapefruit juice can last for a substantial period, possibly as long as several days after the juice is consumed; thus, the interaction cannot be avoided just by separating grapefruit juice consumption from drug administration.

Nutritional Science

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Fill in the blank with correct word

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Monounsaturated fatty acids

What will be an ideal response?

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