Which statement is correct in regard to the muscle relaxant botulinum toxin type B (Myobloc)?
1. It can be classified as a cholinergic agonist.
2. Increased muscle strength is often seen within a couple of weeks.
3. It can take 6 months for the effects to be seen.
4. In high doses, it is poisonous, causing the same symptoms food poisoning does.
Correct Answer: 4
Rationale: Botulinum toxin type B (Myobloc) is toxic in high doses. Clostridium botulinum is the bacteria responsible for food poisoning. The drug works by blocking the release of acetylcholine from cholinergic nerve terminals. It generally takes 6 weeks to see the effects, and they only last for 3–6 months. Patients taking this drug generally experience muscle weakness, not strength.
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