A new drug is developed that targets and binds to the lipid A portion of LPS from Gram-negative bacterial cells. This drug shows a high degree of activity and binding in a test tube setting against purified lipid A. Based on this information,
A. we should fast track this drug and get it out to physicians immediately to help prevent toxic/septic shock in humans.
B. we should do some animal testing with whole Gram-negative cells and the drug before we jump to any conclusions.
C. we should next proceed by moving to testing in a test tube using whole Gram-negative cells to see if it binds with the same strength.
D. we should abandon the drug entirely. Binding to lipid A won't kill the bacteria, so the drug is useless to develop further. It wouldn't help humans who have septic shock at all.
C
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Biuret reagent will indicate the presence of
(a) peptide bonds. (b) proteins. (c) amino acids units linked together. (d) all of the above.
Paired excretory organs found in most body segments of segmented worms are called
a. metanephridia. b. parapodia. c. septa. d. clitella. e. setae.
Hemophilia (h) is a sex-linked recessive trait. If a hemophiliac male marries a carrier female,
a) 50% of their daughters will be hemophiliac. b) 75% of their daughters will be hemophiliac. c) 25% of their daughters will be hemophiliac. d) 75% of their sons will be hemophiliac. e) 25% of their sons will be hemophiliac.
Phosphofructokinase is an important control enzyme in the regulation of cellular respiration. Which of the following statements concerning phosphofructokinase is not true?
A) It is activated by AMP (derived from ADP). B) It is inhibited by ATP. C) It is activated by citrate, an intermediate of the citric acid cycle. D) It specifically catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, an early step of glycolysis. E) It is an allosteric enzyme.