Which of the following factors can increase the lung availability/total systemic availability ratio of inhaled drugs? 1. Efficient delivery devices 2. Inhaled drugs with a high first-pass metabolism rate 3. Mouth washing 4. Use of a reservoir device

a. 1 and 2 only
b. 1 and 3 only
c. 1, 2, and 3 only
d. 1, 2, 3, and 4


ANS: D

Health Professions

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