Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?
a. Blood loss from surgery increases erythrocyte production.
b. Necessary hematopoiesis growth factors produced in the spleen are lost.
c. Removal of the spleen induces the formation of inclusions.
d. The absent spleen cannot "pit" or remove the normally formed inclusions.
ANS: D
Macrophages in the spleen normally remove abnormal inclusions from red cells, which includes Howell-Jolly bodies. This process is called pitting.
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