A physician is providing care for a child who has a diagnosis of cystic fibrosis (CF). Place the following events in the etiology of CF in ascending chronological order. Use all the options
A) Airway obstruction
B) Recurrent pulmonary infections
C) Impaired Cl- transport
D) Decreased water content of mucociliary blanket
E) Increased Na+ absorption
Ans:
C, E, D, A, B
Feedback:
CF is associated with impaired Cl- transport and a consequent increase in Na+ absorption. These result in a lowered water content of the mucociliary blanket making it more viscid. These changes to the mucociliary blanket cause airway obstruction and, ultimately, pulmonary infections.
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