The nursing instructor teaches student nurses about chemotherapy for cancer. Which statement best explains why lung cancers are less sensitive to antineoplastic agents than other types of cancers?
1. "Lung cancer cells have a very erratic cell cycle, and this is why there isn't much difference between the number of replicating and resting cells."
2. "Lung cancer cells have been growing for a long time before detection, so they are less sensitive to antineoplastic agents."
3. "Lung cancer cells have a low-growth fraction, which means there isn't much difference between the number of replicating and resting cells."
4. "Lung cancer cells grow in a high-oxygen environment, so they are not very sensitive to antineoplastic agents."
3
Rationale 1: Lung cancer cells do not have a very erratic cell cycle.
Rationale 2: Lung cancer cells may grow for a long time before detection, but this is not the primary reason they are less susceptible to antineoplastic agents.
Rationale 3: Growth fraction is a ratio of the number of replicating cells to the number of resting cells. Antineoplastic drugs are much more toxic to tissues and tumors with high growth fractions. Breast and lung cancers have low growth fractions.
Rationale 4: A high-oxygen environment is not the reason why lung cancer cells are less sensitive to antineoplastic agents.
Global Rationale: Growth fraction is a ratio of the number of replicating cells to the number of resting cells. Antineoplastic drugs are much more toxic to tissues and tumors with high growth fractions. Breast and lung cancers have low growth fractions. Lung cancer cells do not have a very erratic cell cycle. Lung cancer cells may grow for a long time before detection, but this is not the primary reason they are less susceptible to antineoplastic agents. A high-oxygen environment is not the reason why lung cancer cells are less sensitive to antineoplastic agents.
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