Sarcoidosis is an autoimmune disease that presents with non-specific symptoms of fatigue, fever, and arthralgias. Which of the following signs should raise suspicion of this disorder?
A. Facial rash across nose and cheeks
B. Bilateral hilar lymphadenopathy on chest x-ray
C. Specific tender points on the body
D. Swelling of metacarpophalangeal joints
ANS: B
Sarcoidosis is an inflammatory disorder in which patients develop granulomas and a wide range of symptoms, including arthritis. It is most commonly diagnosed in persons between ages 20 and 40. Arthralgias occur in approximately 3% of patients with sarcoidosis, and the most commonly affected joints include the ankles, feet, and hands. The patient may complain of constitutional symptoms, including fatigue, fever, and altered appetite. Respiratory symptoms, including cough, wheezing, and shortness of breath, are primary symptoms. On chest x-ray, hilar lymphadenopathy and pulmonary granulomas are key diagnostic signs.
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