A client is suspected of having acromegaly. What definitive diagnostic testing is the most reliable method of confirming acromegaly?
A) A serum glucose level
B) Glucose tolerance test in combination with a GH measurement
C) Growth hormone levels
D) Bone radiographs
B
Feedback:
A glucose tolerance test in combination with a GH measurement is the most reliable method of confirming acromegaly. Ingestion of a bolus of glucose should lower GH levels, but GH levels remain elevated in persons with acromegaly. Increased blood levels of IGF-1 can also indicate acromegaly in nonpregnant women; they typically have IGF-1 levels two to three times higher than normal in pregnant women. A serum glucose level is not an indicator of acromegaly. Growth hormone levels and bone radiographs may support the diagnosis but are not reliable indicators.
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