The nurse is reviewing a client's medication and learns that the client has been taking prednisone. What is the nurse's understanding of the effect of prednisone on the adrenal glands?
A) Prednisone therapy results in destruction of the adrenal medulla, thereby decreasing corticotropin releasing hormone.
B) Prednisone therapy can lead to significant toxicity, resulting in dehydration, fever, and hyponatremia.
C) Prednisone therapy increases cortisol and decreases adrenocorticotropic hormone via negative feedback principles.
D) Prednisone therapy increases sodium and water resorption and potassium and hydrogen excretion.
C) Prednisone therapy increases cortisol and decreases adrenocorticotropic hormone via negative feedback principles.
Explanation: A) Prednisone therapy increases cortisol and decreases adrenocorticotropic hormone via negative feedback principles. Prednisone therapy results in destruction of the adrenal cortex, thereby resulting in deficiency of adrenocortical hormones, not corticotropin releasing hormone. Dehydration, fever, hyponatremia, and vascular collapse can result from acute adrenocortical insufficiency (adrenal crisis), not prednisone therapy. Prednisone therapy does not increase sodium and water resorption or potassium and hydrogen excretion.
B) Prednisone therapy increases cortisol and decreases adrenocorticotropic hormone via negative feedback principles. Prednisone therapy results in destruction of the adrenal cortex, thereby resulting in deficiency of adrenocortical hormones, not corticotropin releasing hormone. Dehydration, fever, hyponatremia, and vascular collapse can result from acute adrenocortical insufficiency (adrenal crisis), not prednisone therapy. Prednisone therapy does not increase sodium and water resorption or potassium and hydrogen excretion.
C) Prednisone therapy increases cortisol and decreases adrenocorticotropic hormone via negative feedback principles. Prednisone therapy results in destruction of the adrenal cortex, thereby resulting in deficiency of adrenocortical hormones, not corticotropin releasing hormone. Dehydration, fever, hyponatremia, and vascular collapse can result from acute adrenocortical insufficiency (adrenal crisis), not prednisone therapy. Prednisone therapy does not increase sodium and water resorption or potassium and hydrogen excretion.
D) Prednisone therapy increases cortisol and decreases adrenocorticotropic hormone via negative feedback principles. Prednisone therapy results in destruction of the adrenal cortex, thereby resulting in deficiency of adrenocortical hormones, not corticotropin releasing hormone. Dehydration, fever, hyponatremia, and vascular collapse can result from acute adrenocortical insufficiency (adrenal crisis), not prednisone therapy. Prednisone therapy does not increase sodium and water resorption or potassium and hydrogen excretion.
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