A 60-year-old man complaining of prolonged cough and expectoration for the last 6 months, fatigue, and loss of weight was admitted to the hospital for further studies. A hilar lung mass was found on x-ray, and the blood showed hypercalcemia
The most likely cause of hypercalcemia is a pulmonary
A. adenocarcinoma
B. oat-cell (small cell) carcinoma
C. squamous cell carcinoma
D. carcinoid
E. mesothelioma
C
Hypercalcemia is most often caused by the parathyroid hormone–related protein (PTHrP), a calcium regulatory polypeptide hormone. PTHrP is normally secreted by squamous cells of the skin and can be found in the blood of patients who have squamous cell carcinoma of the bronchi.
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