List the pathophysiology processes involved in appendicitis in sequential order
A) The appendix becomes distended with fluid secreted by its mucosa.
B) Obstruction of the proximal lumen of the appendix is apparent.
C) Purulent exudate formed causes further distention of the appendix.
D) Pressure within the lumen of the appendix increases.
E) Tissue necrosis and gangrene result.
Answer: B, A, D, C, E
Obstruction of the proximal lumen of the appendix is apparent in most acutely inflamed appendices. Following obstruction, the appendix becomes distended with fluid secreted by its mucosa. Pressure within the lumen of the appendix increases, impairs its blood supply, and leads to inflammation, edema, ulceration, and infection. The purulent exudate formed causes further distention of the appendix. If treatment is not initiated, tissue necrosis and gangrene result within 24-36 hours, leading to perforation (rupture).
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