An enzyme-linked immunosorbent assay (ELISA) with platelet factor 4 (PF4) coated to the surface of microplate wells is used for the diagnosis of:
a. Heparin-induced thrombocytopenia
b. Acute immune thrombocytopenic purpura
c. Chronic immune thrombocytopenic purpura
d. Aspirin resistance
ANS: A
An ELISA with PF4 coated to the surface of microplate wells is used for the diagnosis of heparin-induced thrombocytopenia. The principle of this test is based on the fact that the antigenic target of the heparin-dependent antibody is a PF4-heparin complex.
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