Which one of the following terms describes the phenomenon that occurs when the results of two drugs used together have a greater combined effect than when either drug is used alone?
a. Additive effect
b. Synergism
c. Potentiation
d. Antagonism
ANS: B
Synergism describes the results of two drugs whose combined effects are greater than the sum of each drug acting alone. The term is usually reserved for situations where the two drugs are acting at different sites or have different mechanisms of action. One of the drugs, the synergist, in-creases the effect of the second drug by altering its absorption, biotransformation, distribution, or elimination.
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