A client is being treated with dornase alfa (Pulmozyme). The nurse anticipates that the client is most likely to experience which cluster of adverse effects?
1. Headache, nasal stuffiness, and earaches
2. Nausea, vomiting, and diarrhea
3. Epigastric pain, belching, and flatulence
4. Sore throat, conjunctivitis, and hoarseness
Correct Answer: 4
Rationale 1: Headache, nasal stuffiness, and earache are not common adverse effects of Pulmozyme.
Rationale 2: Nausea, vomiting, and diarrhea are not common adverse effects of Pulmozyme.
Rationale 3: Epigastric pain, belching, and flatulence are not common adverseeffects of Pulmozyme.
Rationale 4: The most common adverse effects of Pulmozyme are chest pain, hoarseness, sore throat, and conjunctivitis.
Global Rationale: Dornase alfa (Pulmozyme), is an enzyme that was approved in 1993 for the management of thick bronchial secretions in patients with cystic fibrosis. Dornase alfa breaks down deoxyribonucleic acid (DNA) molecules in the mucus, causing it to become less viscous. It is administered by the oral inhalation route. Adverse effects include chest pain, conjunctivitis, hoarseness, and pharyngitis. The remaining adverse effects are not assocated with Pulmozyme.
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