Which of the following statements about the use of angiotensin-converting enzyme inhibitor medications and autosomal recessive polycystic kidney disease (ARPKD) is accurate?
A) The use of ACE inhibitors will increase the vasopressin levels.
B) ACE inhibitors may interrupt the renin–angiotensin–aldosterone system to reduce renal vasoconstriction.
C) The ACE inhibitors have been shown to shrink the size of the cysts inside the kidneys.
D) ACE inhibitors should be used strictly in those clients who also have an underlying cardiac history.
Ans: B
Feedback:
In addition to increasing water intake to decrease vasopressin levels, the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) may be used to interrupt the renin–angiotensin–aldosterone system as a means of reducing intraglomerular pressure and renal vasoconstriction. Although not approved by the Food and Drug Administration (FDA), there has been recent interest in the use of vasopressin receptor antagonists (vaptans) to decrease cyst development.
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