Twenty-four days after surgery, J.P. is readmitted to the coronary care unit (CCU) after a cardiac biopsy

demonstrates moderate acute rejection.
What is the cause of acute rejection? How does it differ from chronic rejection?

What will be an ideal response?


Acute rejection occurs days to weeks after transplantation. In acute rejection, antigens on the
transplanted heart prompt lymphocytes to mature into helper T cells that, in turn, increase the
production of killer T cells. These killer T cells attack the transplanted heart and cause rejection.
Acute rejection is usually reversible with immunosuppressive therapy. Chronic rejection occurs
3 months to years later and is irreversible. Both T and B lymphocytes infiltrate the heart, causing
immune-mediated injury and fibrosis. Prognosis in chronic rejection varies.

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What is the primary pharmacologic therapy for Candida albicans?

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