The HIV virus can take over much of the cell's machinery to produce many copies of the virus. Two classes of drugs that have been effective against HIV are base analogs (e.g., AZT) and protease inhibitors. How do these work to slow or stop HIV replication? What other steps in the HIV life cycle might be targets for drug development? What else can be done to try to stop the spread of HIV?
What will be an ideal response?
The best responses will include discussions of the following ideas: HIV attachment and movement into the cell; reverse transcription (AZT) and integration of the HIV nucleic acids; production and maturation (protease inhibitors) of viral proteins; assembly of complete viral particles; and continued infection of the population. Possible drugs could target attachment, integration, assembly, and continued infection. The student response to the last question is open but should include discussion of the following topics: education; and means to prevent transmission. Thoughtful answers will discuss the ramifications these changes will have on society and why they have not been implemented or have been ineffective.
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