Why was a recombinant form of the hepatitis B vaccine developed?
1. Concerns about liver immaturity of newborns
2. High number of allergic responses to the original form
3. Problems with virus inactivation by antibodies
4. Risk of HIV transmission with the original form of the vaccine
Correct Answer: 4
Rationale 1: The maturity of the liver of newborns was not a reason the recombinant form of hepatitis B vaccine was developed.
Rationale 2: A recombinant form was not developed due to increased allergic response.
Rationale 3: Virus inactivation was not the driving concern for development of the recombinant form.
Rationale 4: A recombinant form was developed due to fear of HIV transmission.
Global Rationale: Perhaps the best example of the use of this form of biotechnology is for the development of the hepatitis B immunization. It was originally obtained from the serum of infected individuals but carried the risk of transmitting HIV when it was administered as a vaccine. Through advances in recombinant deoxyribonucleic acid (DNA) technology, yeast cells have been reengineered to produce proteins very similar to those found on the coating of the hepatitis B virus, allowing for the development of safe immune protection from this virus. Liver maturity, allergic responses, and virus inactivation were not consideration for this development.
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