The angiogenesis process, which allows tumors to develop new blood vessels, is triggered and regulated by tumor-secreted:
A) Procoagulants
B) Growth factors
C) Attachment factors
D) Proteolytic enzymes
Ans: B
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Many tumors secrete growth factors, which trigger and regulate the angiogenesis process. Tumor cells express various cell surface attachment factors, for anchoring. Tumor cells secrete proteolytic enzymes to degrade the basement membrane and migrate into surrounding tissue. Cancer cells may produce procoagulant materials that affect clotting mechanisms.
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