A student nurse asks the charge nurse the definition of a prodrug. What is the best response by the charge nurse?
1. A prodrug is a name brand drug.
2. A prodrug is not absorbed by the body.
3. A prodrug is the first drug developed in a drug class.
4. A prodrug requires metabolism to make it active.
Correct Answer: 4
Rationale 1: Is a name brand drug is incorrect. A prodrug requires metabolism to make it active. In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug.
Rationale 2: Is not absorbed by the body is incorrect. A prodrug requires metabolism to make it active. In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug.
Rationale 3: Is the first drug developed in a drug class is incorrect. This would be a prototype drug.
Rationale 4: In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug.
Global Rationale: A prodrug requires metabolism to make it active. In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug. A prodrug is not necessarily a brand name drug. A prodrug is absorbed by the body. A prototype drug, not a prodrug, is the first drug developed in a drug class.
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