Following the administration of a loading dose of an antibiotic, the nurse anticipates that the client will receive which dosing schedule of additional antibiotic?
1. A second loading dose
2. Regularly intermittent doses of the antibiotic
3. Alternating high and low doses of the antibiotic
4. Daily bolus injections
Correct Answer: 2
Rationale 1: A loading dose of a medication is usually only given once. Repeating the loading dose could cause toxicity.
Rationale 2: Following a loading dose, the usual maintenance dose of a drug is given in order to maintain a therapeutic blood level of the drug.
Rationale 3: Alternating high and low doses would not allow for a plateau of the drug level to be reached, which is needed for a therapeutic response.
Rationale 4: Bolus injections are usually only given once, not daily.
Global Rationale: Following a loading dose, the usual maintenance dose of a drug is given in order to maintain a therapeutic blood level of the drug. A loading dose of a medication is usually only given once. Repeating the loading dose could cause toxicity. Alternating high and low doses would not allow for a plateau of the drug level to be reached, which is needed for a therapeutic response. Bolus injections are usually only given once, not daily
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