An 8-year-old female presents with edema of the cutaneous and mucosal tissue layers. Her mother reports that the condition is recurrent and seems to occur more often during stressful sit-uations
The child is diagnosed with hereditary angioedema. Which of the following is deficient in this child?
a. C1 esterase inhibitor
b. Carboxypeptidase
c. Neutrophils
d. Plasmin
ANS: A
A genetic defect in C1 esterase inhibitor (C1 INH deficiency) results in hereditary angioedema. Hereditary angioedema is due to C1 esterase inhibitor, not neutrophils. Carboxypeptidase de-grades kinins. Plasmin is associated with clots.
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