A client receiving antineoplastic agents in the treatment of lung cancer has been told that treatment options are limited. The nurse explains that lung cancer has a decreased sensitivity to antineoplastic agents because lung cancer cells:
1. have a very erratic cell cycle, and there is little difference between the number of replicating and resting cells.
2. grow for a long time before detection and are therefore less sensitive to antineoplastic agents.
3. grow in a high-oxygen environment and are therefore not very sensitive to antineoplastic agents.
4. have a low growth fraction, so there is little difference between the number of replicating and resting cells.
Correct Answer: 4
Rationale 1: Lung cancer cells do not have a very erratic cell cycle.
Rationale 2: Lung cancer cells might grow for a long time before detection, but this is not the primary reason they are less susceptible to antineoplastic agents.
Rationale 3: A high-oxygen environment is not the reason that lung cancer cells are less sensitive to antineoplastic agents.
Rationale 4: The growth fraction is the ratio of the number of replicating cells to the number of resting cells. Antineoplastic drugs are much more toxic to tissues and tumors with high growth fractions. Breast and lung cancers have a low growth fraction.
Global Rationale: Solid tumors such as breast and lung cancer generally have a low growth fraction; therefore, they are less sensitive to antineoplastic agents. Lung cancer cells do not have a very erratic cell cycle. Lung cancer cells might grow for a long time before detection, but this is not the primary reason they are less susceptible to antineoplastic agents. A high-oxygen environment is not the reason that lung cancer cells are less sensitive to antineoplastic agents.
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