A patient is brought to the emergency department after ingesting a handful of diphenhydramine (Benadryl) tablets. The patient has dilated pupils, a flushed face, and tremors
The patient is agitated and has a heart rate of 110 beats per minute. The nurse may anticipate administering which agents? (Select all that apply.)
a. Activated charcoal
b. Cathartics
c. Diazepam
d. Phenytoin
e. Second-generation H1 antagonists
ANS: A, B, D
The patient is showing signs of acute antihistamine toxicity. Activated charcoal and cathartics are given to absorb the drug and increase excretion. Phenytoin may be administered for seizures. Diazepam is contraindicated for seizures, because its CNS sedative effects can compound those of diphenhydramine. Second-generation antihistamines are not indicated.
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Subtract: –
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