Explain the functional differences between immature and mature dendritic cells
What will be an ideal response?
Immature dendritic cells are very effective in the process of antigen capture, uptake, and processing. They have specialized pathways of antigen processing for extracellular antigens that can present these antigens on both MHC class I and class II molecules. They do not express co-stimulatory molecules. Immature dendritic cells migrate to nearby lymphoid tissue after antigen ingestion. Upon arrival in the lymphoid tissue, they differentiate into mature dendritic cells. These mature dendritic cells are now non-phagocytic and express the co-stimulatory molecule B7.
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