A health educator is teaching a group of colleagues about the physiology of thermoregulation. Which of the following statements is most accurate?
A)
"Endogenous pyrogens induce host cells to produce exogenous pyrogens."
B)
"Prostaglandin E2 (PGE2) exerts a direct fever-producing effect on the hypothalamus."
C)
"PGE2 induces Kupffer cells to initiate a fever response via hepatic sinusoids."
D)
"Arachidonic acid induces cytokines to act on the temperature regulation center."
Ans:
B
Feedback:
PGE2 is the protein that exerts control on the hypothalamus and induces fever. Exogenous pyrogens induce host cells to produce endogenous pyrogens, and Kupffer cells produce PGE2. Cytokines do not act directly in the hypothalamus.
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