What happens to the fibrin monomers created when thrombin cleaves fibrinopeptides A and B from fibrinogen?
a. Immediately inactivated to prevent excess clotting
b. Converted to plasminogen
c. Digested quickly by tissue plasminogen activator (TPA)
d. Polymerize and are stabilized by factor XIIIa
ANS: D
Once thrombin splits fibrinopeptides A and B from fibrinogen, the fibrin monomers are formed. These spontaneously polymerize to form the initial soluble fibrin polymer, which is cross-linked by XIIIa and then becomes insoluble. Fibrin monomers spontaneously polymerize to form the fibrin clot, which is then stabilized by factor XIIIa. TPA activates plasminogen to plasmin, which lyses the clot.
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