A 22-year-old female with a history of intermittent flank pain, repeated UTIs, and hematuria has been diagnosed with autosomal dominant polycystic kidney disease (ADPKD)
Which of the following phenomena has most likely contributed to the development of this diagnosis?
A)
UTIs coupled with an impaired immune response have caused her ADPKD.
B)
She has inherited a tendency for epithelial cells in her tubules to proliferate inappropriately.
C)
Severe hypertension and portal hypertension are likely precursors.
D)
She has inherited undersized kidneys that are prone to calculi formation.
Ans:
B
Feedback:
ADPKD is an inherited condition, and the etiology is thought to involve cysts arising in segments of the renal tubules from a few epithelial cells that proliferate abnormally. UTIs are consequent, not causative, of the condition. Severe hypertension and portal hypertension are more commonly associated with ARPKD than ADPKD. Kidneys are typically oversized in ADPKD, and renal calculi are not noted sequelae.Ans:
B
Feedback:
ADPKD is an inherited condition, and the etiology is thought to involve cysts arising in segments of the renal tubules from a few epithelial cells that proliferate abnormally. UTIs are consequent, not causative, of the condition. Severe hypertension and portal hypertension are more commonly associated with ARPKD than ADPKD. Kidneys are typically oversized in ADPKD, and renal calculi are not noted sequelae.
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