Phenelzine (Nardil) has been discontinued as a drug order for a patient. How much time must be observed before the patient can start a new drug?
a. 2 days
b. 5 days
c. 1 week
d. 2 weeks
ANS: D
Phenelzine is a monoamine oxidase inhibitor (MAOI) that produces irreversible inhibition of monoamine oxidase. It takes about 2 weeks for sufficient synthesis of new enzyme to occur. Thus the start of a new drug must be delayed for 2 weeks after discontinuing phenelzine.
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