Which factors does the nurse recognize potentially influence oral absorption of drugs in the pediatric client?

Question

1. Increased gastric pH
2. Delayed gastric emptying
3. Immature hepatic cytochrome P450 enzyme system
4. Immaturity of the kidneys
5. High water-to-fat proportion

Answer 1

Correct Answer: 1,2
Rationale 1: Increased gastric pH may enhance the absorption of acid–labile drugs such as ampicillin and penicillin and slow the absorption of weak acids such as Phenobarbital.
Rationale 2: Delayed gastric emptying may keep a drug in the stomach longer, increasing the absorption across the stomach mucosa but slowing the rate of drug absorption for drugs designed to be absorbed in the intestine.
Rationale 3: The immature hepatic cytochrome P450 enzyme system affects metabolism of drugs, not absorption.
Rationale 4: The immaturity of the kidneys affects excretion of drugs, not absorption.
Rationale 5: The high water-to-fat proportion affects distribution of drugs, not absorption.
Global Rationale: Increased gastric pH may enhance the absorption of acid–labile drugs such as ampicillin and penicillin and slow the absorption of weak acids such as Phenobarbital. Delayed gastric emptying may keep a drug in the stomach longer, increasing the absorption across the stomach mucosa but slowing the rate of drug absorption for drugs designed to be absorbed in the intestine. The immature hepatic cytochrome P450 enzyme system affects metabolism of drugs, not absorption. The immaturity of the kidneys affects excretion of drugs, not absorption. The high water-to-fat proportion affects distribution of drugs, not absorption.