A nurse is caring for a patient with a history of advanced liver disease. What should be the primary concern of the nurse when administering multiple medications to this patient?
a. The medications will be subject to the first-pass effect.
b. The medications are not in a bioavailable form to be used by the body.
c. The medications may cause toxicity to the patient.
d. The medications will not be absorbed and will not have a therapeutic effect.
C
Medications administered to a patient with liver disease may cause toxicity, because metabolism of the drugs may be altered, depending on the amount of liver damage.
The likelihood of the first-pass effect cannot be determined by the information provided in this question.
Bioavailability has to do with the formulation of the drug, and because the medication names are not given, this would not be relevant.
The liver does not absorb the drugs, therefore this answer is incorrect.
DIF: Cognitive Level: Analysis REF: p. 38
TOP: Nursing Process: Diagnosis
MSC: NCLEX Client Needs Category: Physiological Integrity: Reduction of Risk Potential
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