Endocrine diseases are often due to loss of hormone (i.e., a hormone deficiency)
Which of the following would cause an endocrine disease that mimicked a protein hormone deficiency without a deficiency in the levels of a circulating protein hormone?
A. inactive prohormone convertase
B. defective exocytotic machinery
C. loss of blood transport proteins
D. defective receptor
E. null mutation in corresponding hormone gene
ANS: D
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