How does the rate of initiation of transcription relate to the similarity of the promoter region to the consensus sequence?

What will be an ideal response?


The ability of the sigma factor of the RNA polymerase holoenzyme to recognize and bind to a promoter sequence (i.e., the efficiency of RNA polymerase binding) is dependent on the similarity of the promoter to the consensus sequence (the sequence found most frequently at each position of the promoter). As a result, the rate at which transcription is initiated varies from gene to gene.

Biology & Microbiology

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